four voltage-gated skeletal muscle ion channels |
Spectrum of altered muscle excitability: The
nondystrophic myotonias and familial periodic paralyses lie along a continuum
of muscle defects ranging from myotonia only to a combination of myotonia and
periodic paralysis to periodic paralysis associated with sever multi-system
involvement. All are caused by defects in the coding regions of voltage-gated
ion channel genes (Stephen C. Cannon, 2002). |